A SYUDY ON THE CLINICAL SYMPTOMS AND CYTOKINES PROFILE IN THE ACUTE ENCEPHALITIS SYNDROME PATIENT
Akarsh Srivastava, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad
The present study was conducted on 40 patients who were admitted to the hospital with encephalitis symptoms. The general clinical feature as per advised by the clinicians were recorded on a precoded proforma. A total of 85% of cases belonged to less than 30 yrs of age, suggesting the disease has higher incidence in younger population. We observed a significant elevation in serum interleukins (RANTES and TNF-α) in the serum of patients with Acute Encephalitis Syndrome as compared to control group. Higher values of interleukins are because of release these proinflammatory mediators from infected cells and persistent hypercytokinemia may result in progression to multiple organ failure. It is known that activation of cytokine networks increases levels of various cytokines in blood. However there was no significant difference in the level of serum IL-6, between patients and control group. Thus understanding the different expression level of cytokines and chemokines in the serum/cerebrospinal fluid of patients suffering with central nervous system infection would lead to pathogenesis of the encephalitis causing viruses. It would also be helpful in understanding their role in inhibition of virus progression and severity of the infection.
Keywords: Encephalitis, Interleukins, Hypercytokinemia, chemokines.